Kantonsspital St.Gallen

Dissecting the association of anti-microbiota antibodies and auto-reactive T-cells in cardiomyopathy– an exploratory research Project

Micha T. Maeder, Susanne Vetsch & Burkhard Ludewig

abstract Prospective research project in which biological material is sampled from humans and health-related personal data is collected (HFV Art 6).
To generate further scientific evidence for a potential role of crossreactive antimicrobial T and B cell responses in patients with heart failure.
i) Determine the levels of anti-heart proteins - and anti-microbiota specific antibodies in serum of patients with newly diagnosed heart failure of non-ischemic origin, patients with active or recent myocarditits/perimyocarditis and controls.
ii) Determine the abundance of heart-reactive and crossreactive antimicrobial effector T cells in PBMCs from patients with heart failure, myocarditis/perimyocarditis and controls.
iii) Determine if the HLA-DQB1*03:01 molecule is linked to the development of cardiac autoimmunity and heart failure
project partner Klinik für Kardiologie KSSG
type of project clinical studies
status ongoing - recruiting phase
start of project 2018
end of project 2020
study design Sampling of biological material and collection of health-related personal data with single center project set-up.
Blood samples will be obtained from patients that fulfill the inclusion criteria, HLA will by typified and antimicrobial crossreactive T and B cell responses will be assessed in the Institute of Immunobiology,
Kantonsspital St. Gallen
responsible person Prof. Dr. Burkhard Ludewig