CardioOnco - Diagnosing Preclinical Cardiac Dysfunction in Adult Childhood Cancer Survivors ‒ The CardioOnco study - Project

Project

CardioOnco - Diagnosing Preclinical Cardiac Dysfunction in Adult Childhood Cancer Survivors ‒ The CardioOnco study

Ongoing - recruitment active · 2021 until 2030

Scheler Eva, Schneider Irene

Type

Clinical Studies

Range

Multicentric, KSSG as participating partner

Units

Kardiologie

Status

Ongoing - recruitment active

Start Date

2021

End Date

2030

Financing

Krebsliga Switzerland

Study Design

Prospective multicentre cohort study in german speaking Switzerland

Keywords

childhood Cancer, cardiac dysfunction

Brief description/objective

We aim to:
1. Assess preclinical cardiac dysfunction longitudinally using 2-dimensional (2D) and 3-dimensional (3D) conventional and 2D speckle tracking echocardiography.
2. Assess cardiopulmonary fitness using cardiopulmonary exercise testing.
3. Determine the association between cardiac dysfunction and treatment-related risk factors (anthracyclines, alkylating agents, steroids, cardiac radiation) and modifiable cardiovascular risk factors (abdominal obesity, hypertension, physical activity, smoking).
4. Study the association between cardiac dysfunction and other self-reported health Outcomes.

Primary Outcomes:
- Abnormal left ventricular ejection fraction (LVEF) by 2D and 3D conventional echocardiography
 - Abnormal global longitudinal strain (GLS) by 2D speckle tracking echocardiography
 -Abnormal peak oxygen uptake (peak VO2) by CPET