Factors to Consider When Assessing the Diagnostic Accuracy of Synovial Leukocyte Count in Periprosthetic Joint Infection

Publication

Factors to Consider When Assessing the Diagnostic Accuracy of Synovial Leukocyte Count in Periprosthetic Joint Infection

Journal Paper/Review - Aug 2, 2019

Ottink Karsten D, Strahm Carol, Muller-Kobold Anneke, Sendi Parham, Wouthuyzen-Bakker Marjan

Citation

Ottink K, Strahm C, Muller-Kobold A, Sendi P, Wouthuyzen-Bakker M. Factors to Consider When Assessing the Diagnostic Accuracy of Synovial Leukocyte Count in Periprosthetic Joint Infection. J Bone Jt Infect 2019; 4:167-173.

Type

Journal Paper/Review (English)

Journal

J Bone Jt Infect 2019; 4

Publication Date

Aug 2, 2019

Issn Print

2206-3552

Pages

167-173

Brief description/objective

Synovial white blood cell (WBC) count and the percentage of polymorphonuclear leucocytes (PMN%) is one of the diagnostic criteria to diagnose a periprosthetic joint infection (PJI). Although the test is widely available, the diagnostic accuracy of proposed cut-off levels are influenced by several factors, such as: the affected joint, co-morbid conditions, the causative microorganism and the gathering and processing of samples in the laboratory. In this narrative review we provide an overview on how and to what extent these factors can affect the synovial WBC count and PMN% in synovial fluid.