Sudden infant death syndrome in infants born to HIV-infected and opiate-using mothers
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abstract
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OBJECTIVE: This study was undertaken to determine the role of opiate
use during pregnancy as a predisposing factor for sudden infant
death syndrome (SIDS) in infants born to HIV-infected mothers.
METHODS: In order to identify all infant deaths and their cause and
association with maternal opiate use, the data of a nationwide
prospective cohort study of HIV-infected mothers and their children
were extracted and analysed for a 13-year period. RESULTS: 24 (5.1%)
infant deaths were observed out of 466 infants followed up until
death or at least 12 months of life. 3 (0.6%) of them were due to
non-accidental trauma and were not associated with maternal opiate
use. 7 (1.5%) died due to SIDS, which was confirmed by autopsy. All
SIDS cases occurred in infants born to mothers reporting use of
opiates during pregnancy (n = 124). The relative risk of SIDS
compared to the general population was 18 (95% CI 9 to 38) for all
infants of HIV-infected mothers, and 69 (95% CI 33 to 141) for those
with intrauterine opiate exposure (p<0.001). CONCLUSIONS:
Compared to the Swiss general population, the risk for SIDS in this
cohort of infants born to HIV-infected mothers was greatly
increased, but only for mothers reporting opiate use during
pregnancy. This effect appeared not to be mediated by prematurity,
low birth weight, perinatal HIV infection or antiretroviral drug
exposure.
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citation
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Kahlert C R, Rudin C, Kind C. Sudden infant death syndrome in
infants born to HIV-infected and opiate-using mothers. Archives of
disease in childhood 2007; 92:1005-8.
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type
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journal paper/review (English)
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date of publishing
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11-2007
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journal title
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Archives of disease in childhood (92/11)
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ISSN electronic
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1468-2044
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pages
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1005-8
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PubMed
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17556395
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DOI
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10.1136/adc.2007.117192
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