Oral valganciclovir in children: single dose pharmacokinetics in a six-year-old girl
Marcus Burri, Hugh Wiltshire, Christian R. Kahlert, George Wouters & Christoph Rudin
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abstract
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We report a pharmacokinetic study in a 6-year-old girl with
congenital human immunodeficiency virus type 1 and cytomegalovirus
coinfection maintained on iv ganciclovir for 6 years. Increasing
infection and thrombosis caused by her iv device necessitated
alternative therapy. Single dose pharmacokinetics of ganciclovir 4.4
mg/kg iv and valganciclovir 13.2 and 26.3 mg/kg po were studied with
high performance liquid chromatography/tandem mass spectrometry. The
two oral dosages yielded areas under the concentration curve of 14.3
and 28.7 microg x h/ml, equivalent to 43% bioavailability of
ganciclovir from valganciclovir, which exceeded the area under the
concentration curve of 11.1 microg x h/ml yielded by ganciclovir 4.4
mg/kg iv. Oral valganciclovir achieved therapeutic and
dosage-proportional plasma concentrations in the child we studied.
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citation
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Burri M, Wiltshire H, Kahlert C R, Wouters G, Rudin C. Oral
valganciclovir in children: single dose pharmacokinetics in a
six-year-old girl. The Pediatric infectious disease journal 2004;
23:263-6.
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type
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journal paper/review (English)
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date of publishing
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3-2004
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journal title
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The Pediatric infectious disease journal (23/3)
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ISSN print
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0891-3668
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pages
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263-6
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PubMed
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15014306
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