Severe COVID-19 is associated with elevated serum IgA and antiphospholipid IgA-antibodies
Omar Hasan Ali, David Bomze, Lorenz Risch, Silvio D Brugger, Matthias Paprotny, Myriam Weber, Sarah Thiel, Lukas Kern, Werner Albrich, Philipp Kohler, Christian R. Kahlert, Pietro Vernazza, Philipp K Bühler, Reto A Schüpbach, Alejandro Gómez-Mejia, Alexandra M Popa, Andreas Bergthaler, Josef M Penninger & Lukas Flatz
Higher total IgA and IgA-aPL were consistently associated with severe illness. These novel data strongly suggest that a vigorous antiviral IgA-response, possibly triggered in the bronchial mucosa, induces systemic autoimmunity.
|citation||Hasan Ali O, Bomze D, Risch L, Brugger S D, Paprotny M, Weber M, Thiel S, Kern L, Albrich W, Kohler P, Kahlert C R, Vernazza P, Bühler P K, Schüpbach R A, Gómez-Mejia A, Popa A M, Bergthaler A, Penninger J M, Flatz L. Severe COVID-19 is associated with elevated serum IgA and antiphospholipid IgA-antibodies. Clin Infect Dis 2020;.|
|type||journal paper/review (English)|
|date of publishing||30-09-2020|
|journal title||Clin Infect Dis|