Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis.

Publication

Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis.

Journal Paper/Review - Jun 1, 2017

Disanto Giulio, Barro Christian, Benkert Pascal, Naegelin Yvonne, Schädelin Sabine, Giardiello Antonella, Zecca Chiara, Blennow Kaj, Zetterberg Henrik, Leppert David, Kappos Ludwig, Gobbi Claudio, Kuhle Jens, Swiss Multiple Sclerosis Cohort Study Group

Citation

Disanto G, Barro C, Benkert P, Naegelin Y, Schädelin S, Giardiello A, Zecca C, Blennow K, Zetterberg H, Leppert D, Kappos L, Gobbi C, Kuhle J, Swiss Multiple Sclerosis Cohort Study Group. Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis. Ann Neurol 2017; 81:857-870.

Type

Journal Paper/Review (English)

Journal

Ann Neurol 2017; 81

Publication Date

Jun 1, 2017

Issn Electronic

1531-8249

Pages

857-870

Brief description/objective

Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations. We explored the value of an ultrasensitive single-molecule array (Simoa) serum NfL (sNfL) assay in multiple sclerosis (MS).