Publication

No Effect of Pegylated Interferon-α on Total HIV-1 DNA Load in HIV-1/HCV Coinfected Patients

Journal Paper/Review - May 25, 2018

Units
PubMed
Doi

Citation
Strouvelle V, Günthard H, Metzner K, Hoffmann M, Darling K, Rauch A, Stöckle M, Kouyos R, Kok Y, Scherrer A, Vongrad V, Braun D, Zurich Primary HIV Infection Study and the Swiss HIV Cohort Study. No Effect of Pegylated Interferon-α on Total HIV-1 DNA Load in HIV-1/HCV Coinfected Patients. J Infect Dis 2018; 217:1883-1888.
Type
Journal Paper/Review (English)
Journal
J Infect Dis 2018; 217
Publication Date
May 25, 2018
Issn Electronic
1537-6613
Pages
1883-1888
Brief description/objective

Pegylated interferon-alpha (pIFN-α) is suggested to lower human immunodeficiency virus type-1 (HIV-1) DNA load in antiretroviral therapy (ART)-treated patients. We studied kinetics of HIV-1 DNA levels in 40 HIV-1/hepatitis C virus (HCV) coinfected patients, treated with pIFN-α for HCV and categorized into 3 groups according to start of ART: chronic HIV-1 infection (n = 22), acute HIV-1 infection (n = 8), no-ART (n = 10). Total HIV-1 DNA levels in 247 peripheral blood mononuclear cell samples were stable before, during, and after pIFN-α treatment in all groups. Our results question the benefit of pIFN-α as an immunotherapeutic agent for reducing the HIV-1 reservoir.