Publication

Maternal outcomes and risk factors for COVID-19 severity among pregnant women

Journal Paper/Review - Jul 6, 2021

Units
PubMed
Doi

Citation
Giannoni E, Lopez-Giron M, Burgos-Luna J, Escobar-Vidarte M, Hecher K, Tallarek A, Hadar E, Haratz K, Amikam U, Malinger G, Maymon R, Yogev Y, Schäffer L, Toussaint A, Rossier M, Calvache A, Derouich M, Granado C, Monod C, Mueller D, Hoesli I, Bassler D, Heldstab S, Kölble N, Sentilhes L, Charvet M, Deprest J, Richter J, Van der Veeken L, Eggel-Hort B, Plantefeve G, De Sa R, Grawe C, Sedille L, Papadia A, Brugger R, Weber B, Fischer T, Kahlert C, Saines K, Cambou M, Kanellos P, Chen X, Yin M, Haessig A, Ackermann S, Baud D, Giral M, Brochut A, Aebi-Popp K, Radan A, Raio L, Surbek D, Böckenhoff P, Strizek B, Kaufmann M, Bloch A, Boulvain M, Johann S, Heldstab S, Bernasconi M, Grant G, Feki A, Panchaud A, Rozenberg P, Vouga M, Castillo K, Solsona E, Trigo L, Cleary B, Geary M, Bartels H, Al-Kharouf F, Malone F, Higgins M, Keating N, Knowles S, Poncelet C, Ribeiro-do-Valle C, Surita F, Hawkins-Villarreal A, Goncé A, Favre G, Martinez-Perez O, Pomar L, Acebal L, Abascal-Saiz A, Hernandez M, Hcini N, Lambert V, Carles G, Sichitiu J, Salomon L, Stirnemann J, Ville Y, de Tejada B, Dantas-Silva A, Borrelli C, Subtil D, Bohrer B, Da Rocha Oppermann M, Wender M, Schuler-Faccini L, Sanseverino M, Giugliani C, Friedrich L, Scherer M, Mottet N, Ducarme G, Pelerin H, Moreau C, Breton B, Garabedian C, Martins I, Luz A, Fuenzalida J, Carvajal J, Canales M, Hernandez O, Grechukhina O, Ko A, Reddy U, Figueiredo R, Moucho M, Pinto P, De Luca C, De Santis M, de Campos D, Quibel T. Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Sci Rep 2021; 11:13898.
Type
Journal Paper/Review (English)
Journal
Sci Rep 2021; 11
Publication Date
Jul 6, 2021
Issn Electronic
2045-2322
Pages
13898
Brief description/objective

Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.