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In this study, a collaborative work with EMBL Heidelberg, ETH- D BSSE Empa (Materials Science and Technology), we deciphered –hitherto unknown- resistance mechanisms of P. aeruginosa to ceftazidime- avibactam (CZA), a novel antibiotic with a multi-omics (genomics, transcriptomics, proteomics) approach. Resistant derivatives were generated by a multistep resistance selection for CZA and meropenem and cross-resistance evaluated. This study is at the stage of genome editing, where we are implementing interesting mutations found in WGS (compared to transcriptome and proteome) into the parental strains.