Publikation

CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte-macrophage colony-stimulating factor-dependent fashion

Wissenschaftlicher Artikel/Review - 22.07.2003

Bereiche
PubMed
DOI

Zitation
Gillessen Sommer S, Dranoff G, Strominger J, Balk S, Taniguchi M, Blumberg R, Luster A, Mach N, Lee F, Exley M, Nieuwenhuis E, Naumov Y, Wilson S. CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte-macrophage colony-stimulating factor-dependent fashion. Proceedings of the National Academy of Sciences of the United States of America 2003; 100:8874-9.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Proceedings of the National Academy of Sciences of the United States of America 2003; 100
Veröffentlichungsdatum
22.07.2003
ISSN (Druck)
0027-8424
Seiten
8874-9
Kurzbeschreibung/Zielsetzung

CD1d-restricted T cells contribute to tumor protection, but their precise roles remain unclear. Here we show that tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor induce the expansion of CD1d-restricted T cells through a mechanism that involves CD1d and macrophage inflammatory protein 2 expression by CD8 alpha-, CD11c+ dendritic cells (DCs). The antitumor immunity stimulated by vaccination with irradiated, granulocyte-macrophage colony-stimulating factor-secreting tumor cells was abrogated in CD1d- and J alpha 281-deficient mice, revealing a critical role for CD1d-restricted T cells in this response. The loss of antitumor immunity was associated with impaired tumor-induced T helper 2 cytokine production, although IFN-gamma secretion and cytotoxicity were preserved. DCs from immunized CD1d-deficient mice showed compromised maturation and function. Together, these results delineate a role for CD1d-restricted T cell-DC cross talk in the shaping of antitumor immunity.