Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis.

Publikation

Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis.

Wissenschaftlicher Artikel/Review - 01.06.2017

Disanto Giulio, Barro Christian, Benkert Pascal, Naegelin Yvonne, Schädelin Sabine, Giardiello Antonella, Zecca Chiara, Blennow Kaj, Zetterberg Henrik, Leppert David, Kappos Ludwig, Gobbi Claudio, Kuhle Jens, Swiss Multiple Sclerosis Cohort Study Group

Zitation

Disanto G, Barro C, Benkert P, Naegelin Y, Schädelin S, Giardiello A, Zecca C, Blennow K, Zetterberg H, Leppert D, Kappos L, Gobbi C, Kuhle J, Swiss Multiple Sclerosis Cohort Study Group. Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis. Ann Neurol 2017; 81:857-870.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Ann Neurol 2017; 81

Veröffentlichungsdatum

01.06.2017

eISSN (Online)

1531-8249

Seiten

857-870

Kurzbeschreibung/Zielsetzung

Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations. We explored the value of an ultrasensitive single-molecule array (Simoa) serum NfL (sNfL) assay in multiple sclerosis (MS).