Projects
Search from 1140 projects:
414 Project(s)
M14-675
Jan 1, 2019A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study to Evaluate the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects with Moderately to Severely Active Ulcerative Colitis
Clinical Studies - Jan 1, 2019 - Aug 1, 2020
Completed
Project leader: Sulz Michael
Members: Brand Stephan, Krieger-Grübel Claudia, Smolders Jolijn
The role of physical activity, malnutrition and sarcopenia for the prediction of acute exacerbations and the evolution of COPD assessment test (CAT) in patients with COPD
Nov 29, 2018We plan to investigate the association between physical activity, malnutrition and sar-copenia and the occurrence of acute exacerbations of COPD (AECOPD) / the evolution of the COPD assessment test (CAT) over 1 year in a telehealthcare (THC) cohort o...
Clinical Studies - Nov 29, 2018 - Jun 30, 2021
Completed
Project leader: Bösch Maximilian
Members: Baty Florent, Rassouli Frank, Tschirren Ursina, Widmer Sandra, Bilz Stefan, Brutsche Martin
Randomisierte klinische Studie zum Vergleich der Vollständigkeit der adjuvanten Chemotherapie nach früher vs. später Stomarückverlagerung bei Patienten mit Rektumkarzinom nach tiefer anteriorer Resektion
Sep 24, 2018Ziel der CoCStom-Studie ist es, den optimalen Zeitpunkt der Rückverlagerung eines künstlichen Darmausgangs (Stoma) zu ermitteln, der im Rahmen der chirurgischen Entfernung des Mastdarms beim lokal fortgeschrittenen Enddarmkrebs (Rektumkarzinom) vorüb...
Clinical Studies - Sep 24, 2018 - Nov 30, 2020
Completed
Project leader: Marti Lukas, Kienle P, Hofheinz R
Members: Beutner Ulrich, Gueller Ulrich, Brunner Walter, Bischofberger Stephan
A Phase 1 Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 Administered Intrathecally to Adults with C9ORF72-Associated Amyotrophic Lateral Sclerosis
Sep 10, 2018The primary objective of this study is to evaluate the safety and tolerability of BIIB078 in adults with C9ORF72-Amyotrophic Lateral Sclerosis (ALS). The secondary objectives of this study are to evaluate the pharmacokinetic profile of BIIB078 and to...
Clinical Studies - Sep 10, 2018 - Nov 17, 2021
Completed
Project leader: Weber Markus
Members: Neuwirth Christoph, Braun Nathalie
Abbvie M15-925: A Phase 3, Randomized, Active-Controlled,
Aug 15, 2018
Clinical Studies - Aug 15, 2018 - Aug 16, 2024
Completed
Project leader: Hutz Carina Liane, Rubbert-Roth Andrea
Members: Bartz-Batliner Mira, Neumann Thomas
Deciphering the transcriptomic landscape of cancer-associated fibroblasts in pancreatic cancer – an exploratory clinical study
Jul 1, 2018Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancer types with a 5-year survival of only 7% 1. While surgical resection of localized disease offers a moderate increase in survival, patients with metastatic pancreas cancer are...
Fundamental Research - Jul 1, 2018 - Dec 31, 2018
Completed
Project leader: Ludewig Burkhard
Members: Lütge Mechthild
STEP 4
Jun 5, 2018Effect and safety of semaglutide 2.4 mg once-weekly in subjects with overweight or obesity who have reached target dose during run-in period
Clinical Studies - Jun 5, 2018 - May 31, 2020
Completed
Project leader: Bilz Stefan
Members: Sigrist Sarah, Aczel Stefan, Räss Andrea
Skippain
Jan 29, 2018SKIPPAIN (Speed of onset of SecuKinumab-Induced relief from Pain in Patients with AxIal SpoNdyloarthritis) A 24-week, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of secukinumab in controlling sp...
Clinical Studies - Jan 29, 2018 - Jun 29, 2019
Completed
Project leader: Rubbert-Roth Andrea
Members: Hutz Carina Liane, Forrer Silvia, Bartz-Batliner Mira
Dissecting the association of anti-microbiota antibodies and auto-reactive T-cells in cardiomyopathy– an exploratory research Project
Jan 25, 2018Prospective research project in which biological material is sampled from humans and health-related personal data is collected (HFV Art 6). To generate further scientific evidence for a potential role of crossreactive antimicrobial T and B cell respo...
Clinical Studies - Jan 25, 2018 - Aug 25, 2021
Completed
Project leader: Ludewig Burkhard
Members: Maeder Micha, Vetsch Susanne
Neuropeptide Y NPY-Trial bei Phäochromozytom
Jan 1, 2018Mesure des taux circulants des métabolites du neuropeptide Y chez les volontaires sains, patients hypertendus et patients atteints d’une tumeur neuroendocrine dans le plasma par une nouvelle méthode analytique utilisant la chromatographie liquide cou...
Clinical Studies - Jan 1, 2018 - Jan 1, 2022
Completed
Project leader: Sigrist Sarah
Members: Bilz Stefan, Räss Andrea
I6T-MC-AMAN
Jan 1, 2018A Phase 3, Multicenter, Randomized, Double-Blind, Parallel, Placebo-Controlled Induction Study of Mirikizumab in Conventional-Failed and Biologic-Failed Patients with Moderately to Severely Active Ulcerative Colitis LUCENT 1
Clinical Studies - Jan 1, 2018 - Feb 1, 2021
Completed
Project leader: Brand Stephan
Members: Krieger-Grübel Claudia, Sulz Michael, Smolders Jolijn
ACRE
Jan 1, 2018A MULTICENTER, MULTI-NATIONAL, RANDOMISED, DOUBLE-BLIND, PLACEBO CONTROLLED, PARALLEL GROUP, PHASE IIA STUDY TO EVALUATE THE EFFICACY, SAFETY AND TOLERABILITY OF AN ANTHOCYANIN RICH EXTRACT (ACRE) IN PATIENTS WITH ULCERATIVE COLITIS.
Clinical Studies - Jan 1, 2018 - Jul 1, 2021
Completed
Project leader: Brand Stephan
Members: Stillhard Roman, Sulz Michael, Krieger-Grübel Claudia, Smolders Jolijn
PIONEER 7
Dec 8, 2017Eine Studie zur Untersuchung der Wirksamkeit und Sicherheit von oralem Semaglutid unter Verwendung einer flexiblen Dosisanpassung bei Patienten mit Typ 2 Diabetes Mellitus im Vergleich zu Sitagliptin
Clinical Studies - Dec 8, 2017 - Jul 31, 2019
Completed
Project leader: Bilz Stefan
Members: Drescher Tilman, Räss Andrea
Lilly RHCF SPIRIT
Oct 16, 2017A 52-Week Multicenter, Randomized, Open-Label, Parallel- Group Study Evaluating the Efficacy and Safety of Ixekizumab versus Adalimumab in Patients with Psoriatic Arthritis Who Are Biologic Disease-Modifying Anti-Rheumatic Drug Naive
Clinical Studies - Oct 16, 2017 - Oct 24, 2021
Completed
Project leader: Rubbert-Roth Andrea
Members: Bartz-Batliner Mira, Forrer Silvia, Hutz Carina Liane, Neumann Thomas
Anal Mapping Biopsies for Human Papilloma Virus (HPV) Associated Lesions
Oct 4, 2017Es gibt keinen eindeutigen Goldstandard für die Diagnose von HPV-assoziierten Analläsionen. Die übliche Diagnostik erfolgt mittels hochauflösender Anoskopie (HRA). Die diagnostische Genauigkeit dieser Methode ist jedoch unklar und stark vom Prüfer ab...
Clinical Studies - Oct 4, 2017 - Feb 4, 2018
Completed
Project leader: Baumeler Stephan, Borovicka Jan, Marti Lukas
Members: Maurus Christine
SERVE - Effect of phosphodiesterase-5 inhibition with Tadalafil on SystEmic Right VEntricular size and function
Oct 1, 2017This study assesses in a pilot trial the effect of PDE-5 inhibition with Tadalafil on RV size and function, exercise capacity and neurohumoral activation in adults with a systemic RV over a 3-year follow-up period. Included patients: Adults (≥18 year...
Clinical Studies - Oct 1, 2017 - Jul 1, 2021
Completed
Project leader: Engel Reto
Members: Gemperle Michaela
ECARA
Sep 1, 2017Beobachtungsstudie Exploration des klinischen Nutzens von Evolocumab in Kombination mit einem e-Health-System: Schweizerische prospektive Beobachtungsstudie an Patienten mit klinisch manifester atherosklerotischer Herz-Kreislauf-Erkrankung (ASCVD) (E...
Clinical Studies - Sep 1, 2017 - Dec 31, 2018
Completed
Project leader: Bilz Stefan
Members: Dehos Barbara, Räss Andrea
ICL670, Deferasirox
Aug 1, 2017A phase II, multicenter, open-label, randomized two-year study to evaluate the efficacy and safety of deferasirox film-coated tablet versus phlebotomy in patients with Hereditary Hemochromatosis
Clinical Studies - Aug 1, 2017 - Jan 1, 2020
Completed
Project leader: Semela David
Members: Stillhard Roman
LEADERS FREE III
Aug 1, 2017A study evaluating the safety and efficacy of the BioFreedomTM Biolimus A9TM coated Cobalt Chromium coronary stent system in patients at high risk of bleeding. The objective of this study is to evaluate if the BioFreedomTM CoCr Drug Coated stent has...
Clinical Studies - Aug 1, 2017 - Dec 31, 2021
Completed
Project leader: Weilenmann Daniel
Members: Vetsch Susanne
ENTRUST DSE-EDO-01-15-EU
Jul 7, 2017Beurteilung der Sicherheit und Wirksamkeit eines Edoxabanbasierten , verglichen mit einem Vitamin-K-Antagonist-basierten, antithrombotischen Therapieregimes nach einer erfolgreichen perkutanen Koronarintervention (PCI) mit Stent-Implantation, bei Pat...
Clinical Studies - Jul 7, 2017 - Jul 7, 2021
Completed
Project leader: Rickli Hans
Members: Gemperle Michaela