Project

CaCo: Does caffeine intake reduce postoperative bowel paralysis after elective laparoscopic colectomy? - A randomized placebo controlled trial

Automatically Closed ยท 2015 until 2022

Type
Clinical Studies
Range
Monocentric project at KSSG
Units
Status
Automatically Closed
Start Date
2015
End Date
2022
Financing
Others
Study Design
Interventional Allocation: randomized Intervention model: parallel assignment Masking: double blind Primary purpose: prevention
Keywords
caffeine, bowel paralysis, colectomy, ileus, surgery
Brief description/objective

Background
Postoperative bowel paralysis is common after abdominal operations, including colectomy. As a result, hospitalization may be prolonged leading to increased cost. A recent randomized controlled trial from the University of Heidelberg showed that consumption of regular black coffee after colectomy is safe and associated with a significantly faster resumption of intestinal motility. The mechanism how coffee stimulates intestinal motility is unknown but caffeine seems to be the most likely stimulating agent.

Aim
Investigation of the effects of caffeine on the return of bowel function and appetite, length of hospital stay, and complications after elective laparoscopic colectomy.

Intervention
Arm 1: postoperative intake of 3x placebo daily
Arm 2: postoperative intake of 3x 100 mg caffeine daily
Arm 3: postoperative intake of 3x 200 mg caffeine daily