After tumor removal, patients with hormone receptor posi-tive breast
cancer often receive adjuvant endocrine treat-ment, with the use of
an aromatase inhibitor (AI) being standard of care in the population
of postmenopausal women. Common side effects of AI therapy are joint
pain, muscle pain, stiffness, fatigue, hot flashes, and weight gain.
Arthralgia and/or myalgia can result in lower physical activity and
can negatively influence quality of life (QoL). In addition, muscle
or joint pain/stiffness are among the main reasons for
non-compliance and discontinuation of AI therapy. Because AI therapy
is usually administered for 5 and sometimes even 10 years, this is a
major clinical challenge.
For breast cancer patients undergoing AI therapy, physical activity can provide potential benefit by reducing mus-cle/joint pain and fatigue and can thus improve QoL. The preventive effect of physical activity on AI side effects, however, remains elusive. In addition, activity programs to reduce AI side effects have so far mostly been rather com-plex. The intervention planned in this study begins at the start of AI therapy, is simple and should therefore be exe-cutable under real life conditions, and has the potential to result in sustained alterations in life style. It consists of a simple, home-based intervention aiming at achieving “brisk recreational outdoor walking (moderate intensity) continu-ously for at least 30 minutes a day, with the aim to take at least 3000 steps, on 5 days per week”.
|type of project||fundamental research|
|start of project||2019|
|end of project||2024|
|project manager||Salome Riniker|