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CardioOnco - Diagnosing Preclinical Cardiac Dysfunction in Adult Childhood Cancer Survivors ‒ The CardioOnco study

Irene Schneider

abstract

We aim to:
1. Assess preclinical cardiac dysfunction longitudinally using 2-dimensional (2D) and 3-dimensional (3D) conventional and 2D speckle tracking echocardiography.
2. Assess cardiopulmonary fitness using cardiopulmonary exercise testing.
3. Determine the association between cardiac dysfunction and treatment-related risk factors (anthracyclines, alkylating agents, steroids, cardiac radiation) and modifiable cardiovascular risk factors (abdominal obesity, hypertension, physical activity, smoking).
4. Study the association between cardiac dysfunction and other self-reported health Outcomes.

Primary Outcomes:
- Abnormal left ventricular ejection fraction (LVEF) by 2D and 3D conventional echocardiography
 - Abnormal global longitudinal strain (GLS) by 2D speckle tracking echocardiography
 -Abnormal peak oxygen uptake (peak VO2) by CPET
   
type of project clinical studies
status scheduled
start of project 2020
end of project 2026
study design Prospective multicentre cohort study in german speaking Switzerland
responsible person Dr. Eva Scheler