Kantonsspital St.Gallen
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BMS CA224-104 Phase 2 Randomized Double-blind Study of Relatlimab plus Nivolumab in Combination with Chemothera-py vs. Nivolumab in Combination with Chemotherapy as First Line Treatment for Participants with Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)

abstract Immunotherapy plays substantial role in first line treatment of NSCLC Stage IV. Current standard of care is – depending on PD-L1 expression- anti-PD-(L)1 alone or in combination with PDCT which has demonstrated significant improvements in OS as well as PFS over chemotherapy. The rationale for combining a LAG-3 inhibitor and and anti-PD-1/PD-L1 agent is based on evidence that LAG-3 has a potential role in T reg suppression and anti-PD-1 resistance and the combination could further improve outcomes.
   
type of project clinical studies
status ongoing - recruiting phase
start of project 2021
end of project 2025
study design Phase II
responsible person Dr. Susanne Weindler