Human airway epithelia and pneumococcus. Polarized in vitro cell culture model to study interaction between human airway epithelia and pneumococcus
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abstract
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This project aims to extend the existing human airway epithelial
model to enable studies on the most relevant and lethal respiratory
bacterial pathogen, Streptococcus pneumoniae (SP). The primary goal
of this proposal is to show the feasibility of the HAE model for
pneumococcal infection. We hypothesize that this HAE model allows us
to study (i) pneumococcal colonization by demonstrating the presence
of SP in the apical layer, (ii) pneumococcal invasive infection by
demonstrating the presence of SP in the basal layer, (iii) the
transition from colonization to invasive infection by demonstrating
the penetration of SP through the HAE into the basal layer, and (iv)
pathogenicity of pneumococcal infection by demonstrating both
cytotoxicity and inflammatory host response through an increased
transcriptional activity of the HAE cells.
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type of project
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fundamental research
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status
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automatically closed
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start of project
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2014
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end of project
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2014
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project manager
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Werner Albrich, Christian Kahlert
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