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The rationale for this study comes from preclinical models, in which lenvatinib decreased the tumor-associated macrophage (TAM) population, which is known as an immune-regulator in the tumor microenvironment. The decrease in TAM population was accompanied by an increase in activated cytotoxic T-cell populations through stimulation of ...
TRK fusion cancer is rare but presents as a variety of solid
tumors. Larotrectinib is a highly selective TRK inhibitor
that, in a pooled analysis of patients in phase 1/2 clinical
trials, demonstrated an effective and sustained response in
the majority of patients with TRK fusion cancer.
Because of the limited number of patients treated ...
BAY-1895344 und Pembrolizumab bei ausgewählten Tumoren
mit genetischen Alterationen von ATM.
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