Kantonsspital St.Gallen


Peter Ammann, David Altmann, Michaela Gemperle & Karin Fink


Health consequences of the Burden of atrial fibrillation

The added information of measuring AF burden and
measuring cardiac dimensions and function in an AF patient population
where brain MRIs are available, could provide further evidence towards a better understanding of the correlation between AF and stroke.
Prospective Holter data and continuous monitoring with implantable
devices in unselected AF populations are scarce and the clinical
relevance of a potential decrease in AF burden has not been described
yet. Holter monitoring at baseline and one year thereafter in the whole
Swiss-AF BURDEN cohort and continuous rhythm monitoring in a
subgroup with implantable loop recorders (ILR) will allow us to 1.)
precisely assess the time in AF and 2.) to assess the change in AF
burden during prospective follow-up. This is important as it remains
currently unknown whether a clear threshold exists or whether the risk of stroke and other adverse outcome events increases continuously with increasing AF burden. We have started Swiss-AF-BURDEN with a pilot study (Swiss-AFBURDEN Pilot study) that showed feasibility.
The aim of this study is to increase our knowledge on the association
between AF burden, change in AF burden and its health consequences,
mainly stroke, systemic embolism and cognitive dysfunction
project partner Universitätsspital Basel
type of project clinical studies
status ongoing - follow up
start of project 2020
study design prospective, multicenter, observational cohort study
responsible person Prof. Peter Ammann