Kantonsspital St.Gallen
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Pleural pharmacokinetics of moxifloxacin and amoxicillin-clavulanate in the context of parapneumonic pleural effusions and empyema

Katia Boggian, Markus Joerger, Florent Baty & Martin Brutsche

abstract The main objective of the study is the characterization of the PK profiles of moxifloxacin and amoxicillin clavulanate in the pleural fluid of patients with parapneumonic effusions using population PK-analysis. Intra- and interpatient variability will be assessed, and the quantitative influence of various covariates on the PK-profile of both drugs will be assessed.
   
type of project clinical studies
status completed
start of project 2011
end of project 2012
study design Within-patient design, clinical pharmacology (PK/PD) phase IV study
responsible person Prof. Dr. Martin Brutsche