The role of the sensory trick in gating multimodal afferents in adult-onset idiopathic cervical dystonia
The ‘sensory trick’ (ST) refers to a particular
manoeuver e.g. slightly touching the face, which is capable of
significantly ameliorating the abnormal head posture in patients
with cervical dystonia (CD) (synonym: torticollis). The benefit is
sometimes quite impressive thus underpinning the need of a better
understanding of this intriguing phenomenon, particularly with
regard to developing alternative treatment approaches. It has been
proposed that the benefit from a ST might reflect normalisation of a
demonstrably abnormal processing of sensory information from the
neck muscles in this condition. Unfortunately the ST often gets lost
as the disease progresses.
In a previous study, we could show that CD patients with a ST (CD+ST) are as responsive to sensory information from the neck muscles as healthy volunteers, whereas patients without a ST (CD-ST) were much less sensitive. This effect, however, was more of a general trait rather than a ST specific effect. Hence it must be assumed that additional mechanisms come into play, when an effective ST is performed. Since information from the vestibulum seems to be widely unaffected in CD patients it is hypothesized that the ST shifts the emphasis from sensory information from the neck muscles towards vestibular Information for head posture control. Because the ST is linked to a particular manoeuvre, it is also assumed that specific sensory information from the arm muscles is an additional prerequisite for the benefit from the ST.
In this project we will use the established paradigms of body sways induced by dorsal neck muscle vibration and galvanic vestibular stimulation as models for vestibular and sensory information processing, respectively, to test these hypotheses. Furthermore, vibration of the arm muscles will be used to modulate sensory information from the limb during the use of the ST. 15 CD+ST, 15 CD-ST and 15 healthy controls will be recruited and will be investigated by the means of a balance analysis.
|type of project||fundamental research|
|start of project||2018|
|end of project||2020|
|project manager||Florian Brugger/Georg Kägi|