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Respiratory bronchiolitis-interstitial lung disease: A rare complication of smoking

Frank Rassouli, Regulo Rodriguez, Jörg-Thomas Kluckert & Martin Brutsche

abstract A 58-year-old male and a 52-year-old female, both active smokers, presented an incidental finding of bilateral miliary, centrilobular, diffuse ground glass-like opacities on their chest CT. The differential diagnosis
is broad and includes miliary tuberculosis and vasculitis and could be ruled out after bronchoalveolar lavage and transbronchial biopsies. Lung cryobiopsy revealed interstitial and intraalveolar accumulation of
brownish pigmented alveolar macrophages with small, fine-granular, anthracotic particles, i.e. “smokers
macrophages”. The diagnosis of bronchiolitis-interstitial lung disease was retained at the institutional multidisciplinary ILD-board. Partial and complete remission was observed after smoking cessation.
   
keywords Bilateral miliary; CT; Tuberculosis; Lung
   
citation Rassouli F, Rodriguez R, Kluckert J T, Brutsche M. Respiratory bronchiolitis-interstitial lung disease: A rare complication of smoking. Open Journal of Clinical & Medical Case Reports 2022; 8 (2022):.
   
type journal paper/review (English)
date of publishing 15-7-2022
journal title Open Journal of Clinical & Medical Case Reports (8 (2022)/09)
ISSN electronic 2379-1039
link https://www.researchgate.net/publication/362230747_Open_Journal_of_Clinical_Medical_Respiratory_bronchiolitis-interstitial_lung_disease_A_rare_complication_of_smoking
contact Jörg-Thomas Kluckert