Diagnostic relevance of direct immunofluorescence in ocular mucous membrane pemphigoid

Publication

Diagnostic relevance of direct immunofluorescence in ocular mucous membrane pemphigoid

Journal Paper/Review - Dec 1, 2015

Mehra Tarun, Guenova Emmanuella, Dechent Frieder, Würth Florian, Zierhut Manfred, Röcken Martin, Schaller Martin, Deuter Christoph

Citation

Mehra T, Guenova E, Dechent F, Würth F, Zierhut M, Röcken M, Schaller M, Deuter C. Diagnostic relevance of direct immunofluorescence in ocular mucous membrane pemphigoid. J Dtsch Dermatol Ges 2015; 13:1268-74.

Type

Journal Paper/Review (English)

Journal

J Dtsch Dermatol Ges 2015; 13

Publication Date

Dec 1, 2015

Issn Electronic

1610-0387

Pages

1268-74

Brief description/objective

BACKGROUND AND OBJECTIVES
The objective was to determine the diagnostic value of direct immunofluorescence (DIF) in ocular mucous membrane pemphigoid (ocular MMP), taking into account immunofluorescence patterns and biopsy sites.

PATIENTS AND METHODS
DIF results and medical records of 54 patients with a suspected diagnosis of ocular MMP were reviewed.

RESULTS
There was an overall prevalence of ocular MMP in 70.4 % of cases. Linear deposition of IgA, IgG, or C3 showed a high positive predictive value (84-100 %). Sensitivity and negative predictive value of IgG, IgM, IgG, and C3 in DIF were higher in cutaneous samples than in conjunctival biopsies, thus yielding a higher diagnostic accuracy. The sensitivity of DIF in ocular MMP seems to be lower than in bullous pemphigoid.

CONCLUSIONS
The diagnostic value of DIF in the workup of ocular MMP was confirmed. However, biopsies taken from non-conjunctival, cutaneous tissue appear to yield more accurate results.