Treatment of pyoderma gangrenosum with topical factor XIII

Publication

Treatment of pyoderma gangrenosum with topical factor XIII

Journal Paper/Review - Sep 1, 2013

Hoetzenecker Wolfram, Guenova Emmanuella, Mitev Vanyo, Schanz Stefan, Ulmer Anja, Fierlbeck Gerhard

Citation

Hoetzenecker W, Guenova E, Mitev V, Schanz S, Ulmer A, Fierlbeck G. Treatment of pyoderma gangrenosum with topical factor XIII. Eur J Dermatol 2013; 23:653-7.

Type

Journal Paper/Review (English)

Journal

Eur J Dermatol 2013; 23

Publication Date

Sep 1, 2013

Issn Electronic

1952-4013

Pages

653-7

Brief description/objective

Pyoderma gangrenosum (PG) is a severe ulcerative skin disease. Despite systemic immunosuppressive therapy, PG ulcers often progress and can develop into life-threatening conditions. In this case series, we treated 6 patients suffering from recalcitrant PG with topical coagulation factor XIII, which has been shown to exert beneficial effects on tissue regeneration and wound healing. All 6 patients showed a positive response to treatment with a marked reduction in wound size that was maintained during a 3-month follow-up period. The treatment was well tolerated with no remarkable adverse effects or complications. Topical factor XIII has potential in combination with standard immunosuppressive therapy for the treatment of PG.