Kantonsspital St.Gallen
login

Chronic hand eczema: A prospective analysis of the Swiss CARPE registry focusing on factors associated with clinical and quality of life improvement

Simone Cazzaniga, Barbara Ballmer-Weber, Nora Gräni, Philippe Spring, Andreas Bircher, Mark Anliker, Anne-Katharina Sonntag, Pierre Piletta, Caroline Huber, Thomas L Diepgen, Christian Apfelbacher, Luigi Naldi, Luca Borradori & Dagmar Simon

abstract

BACKGROUND
Hand eczema (HE) is common and may follow a chronic disease course. So far, prospective studies investigating the risk factors for disease progression as a prerequisite for targeted prevention are scarce.

OBJECTIVE
To evaluate the overall association of HE-associated factors with clinical and quality of life (QoL) improvement during a follow-up of 2 years.

METHODS
Data of the prospective patient cohort (N = 199) followed by the Swiss chronic HE (CHE) registry on long-term patient management (CARPE-CH) were analysed by means of both classic regression and semantic map analyses.

RESULTS
Both severity of HE and QoL significantly improved over the period of 2 years (P < .001). However, 20% of patients had moderate to severe HE after 2 years of follow-up. As factors associated with an unfavourable CHE clinical course and QoL, environmental exposures, male sex, occupational skin disease, job loss or change at baseline, allergic contact dermatitis, a chronic disease course, palmar localization and widespread eczema were identified.

CONCLUSIONS
Analysis of prospective data from CARPE-CH shows a complex pattern of associations among variables as shown by semantic map and classic statistical analyses. Factors related to occupational exposure had the highest impact on CHE.
   
citation Cazzaniga S, Ballmer-Weber B, Gräni N, Spring P, Bircher A, Anliker M, Sonntag A K, Piletta P, Huber C, Diepgen T L, Apfelbacher C, Naldi L, Borradori L, Simon D. Chronic hand eczema: A prospective analysis of the Swiss CARPE registry focusing on factors associated with clinical and quality of life improvement. Contact Derm 2018; 79:136-148.
   
type journal paper/review (English)
date of publishing 25-06-2018
journal title Contact Derm (79/3)
ISSN electronic 1600-0536
pages 136-148
PubMed 29943397
DOI 10.1111/cod.13041