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Fibroblasts in cancer: Defining target structures for therapeutic intervention

Maximilian Bösch, Florent Baty, Holger Rumpold, Sieghart Sopper, Dominik Wolf & Martin Brutsche

abstract The functional importance of the tumor stroma for cancer growth and progression is increasingly recognized, but has not resulted in notable therapeutic developments yet. Within the mesenchymal tumor microenvironment, cancer-associated fibroblasts take the center stage and fuel tumor progression in various ways including malignant cell potentiation, immune regulation and fibrosis. However, recent studies have demonstrated pronounced heterogeneity of the fibroblastic tumor stroma, which comprises a plethora of individual cell subsets with varying phenotypes and functions, some of which suppress malignant growth through immune engagement or crosstalk with the tumor vasculature. This article summarizes the various levels at which the fibroblastic tumor stroma may impact cancer progression and highlights potential target structures for future therapeutic intervention(s).
   
citation Bösch M, Baty F, Rumpold H, Sopper S, Wolf D, Brutsche M. Fibroblasts in cancer: Defining target structures for therapeutic intervention. Biochim Biophys Acta Rev Cancer 2019; 1872:111-121.
   
type journal paper/review (English)
date of publishing 29-06-2019
journal title Biochim Biophys Acta Rev Cancer (1872/1)
ISSN electronic 1879-2561
pages 111-121
PubMed 31265878
DOI 10.1016/j.bbcan.2019.06.003