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Nano-analytical characterization of endogenous minerals in healthy placental tissue: mineral distribution, composition and ultrastructure

Alexandre H C Anthis, Elena Tsolaki, Louis Didierlaurent, Samuel Staubli, Robert Zboray, Antonia Neels, Dörthe Dietrich, Pius Manser, Lotus May Desbiolles, Sebastian Leschka, Simon Wildermuth, Sandro Lehner, Pascale Chavatte-Palmer, Wolfram Jochum, Peter Wick, Alex Dommann, Tina Bürki-Turnherr, Tina Fischer, René Hornung, Sergio Bertazzo & Inge K Herrmann

abstract Despite its crucial role, the placenta is the least understood human organ. Recent clinical studies indicate a direct association between placental calcification and maternal and offspring health. This study reveals distinct characteristics of minerals formed during gestational ageing using cutting-edge nano-analytical characterization and paves the way for investigations focused on the identification of potential markers for disease risks in a clinical setting based on atypical placental mineral fingerprints.
   
citation Anthis A H C, Tsolaki E, Didierlaurent L, Staubli S, Zboray R, Neels A, Dietrich D, Manser P, Desbiolles L M, Leschka S, Wildermuth S, Lehner S, Chavatte-Palmer P, Jochum W, Wick P, Dommann A, Bürki-Turnherr T, Fischer T, Hornung R, Bertazzo S, Herrmann I K. Nano-analytical characterization of endogenous minerals in healthy placental tissue: mineral distribution, composition and ultrastructure. Analyst 2019; 144:6850-6857.
   
type journal paper/review (English)
date of publishing 18-11-2019
journal title Analyst (144/23)
ISSN electronic 1364-5528
pages 6850-6857
PubMed 31591608
DOI 10.1039/c9an01312a