Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland

Publication

Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland

Journal Paper/Review - Jul 13, 2020

Coste A T, Lamoth F, Sanglard D, Bachmann D, Riat A, Neofytos D, Boggian Katia, Zehnder C, Garzoni C, Goldenberger D, Khanna N, Li J, Kritikos A, Fungal Infection Network of Switzerland (FUNGINOS)

Citation

Coste A, Lamoth F, Sanglard D, Bachmann D, Riat A, Neofytos D, Boggian K, Zehnder C, Garzoni C, Goldenberger D, Khanna N, Li J, Kritikos A, Fungal Infection Network of Switzerland (FUNGINOS). Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland. Infection 2020

Type

Journal Paper/Review (English)

Journal

Infection 2020

Publication Date

Jul 13, 2020

Issn Electronic

1439-0973

Brief description/objective

Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15-77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%.