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Two-year follow-up after a six-week high-intensity training intervention study with breast cancer patients: physiological, psychological and immunological differences

Sebastian V W Schulz, Uwe Schumann, Stephanie Otto, Johannes Kirsten, Gunnar Treff, Wolfgang Janni, Jens Huober, Elena Leinert, Jürgen M Steinacker & Daniel A Bizjak

abstract

PURPOSE
Previously we demonstrated the feasibility of a six-week-long combination of high-intensity interval endurance and strength training (HIT/HIRT) for women with nonmetastatic breast cancer leading to improvements in psychological well-being and performance. Now we report results of a 24-month follow-up.

METHODS
Previous intervention (IG,  = 10; 58.7 ± 8.4yrs) and control group (CG,  = 9; 58.8 ± 6.6yrs) were asked for follow-up examinations 12 (T12) and 24 months (T24) after cessation of the supervised training (POST). Medical history, mental well-being, performance and immunological variables were analyzed with respect to intervention start (PRE).

RESULTS
IG maximum oxygen consumption (⩒O) 12%-improved POST ( = 0.05) and declined to baseline values T24, while CG ⩒O increased 12% T24 ( = 0.01). IG strength (1RM) increased 31% POST ( < 0.001) and remained above baseline level T24 ( = 0.003), whereas CG 1RM slightly improved T24 (+19%,  = 0.034). IG Anxiety and Depression decreased POST and did not change until T24. IG C-reactive protein decreased POST and increased to pre-exercise levels T24. CG immunological/inflammatory/life quality markers did not change.

CONCLUSIONS
Six weeks of HIT/HIRT by breast cancer patients can induce similar beneficial effects like two years of convalescence, but outcomes were unstable and showed a fast backslide in aerobic capacity, activity level and in pro-inflammatory state within 12 months.IMPLICATIONS FOR REHABILITATIONHigh-intensity interval endurance and strength training (HIT/HIRT) for female breast cancer patients was shown to improve psychological well-being and performance, but long-term effects/adherence are unknown.Significant backslides in aerobic capacity, activity level as well as in the pro-inflammatory response after one and two years are observed and should be monitored.Continuous supervision and/or support of breast cancer patients before, during, and after medical care due to poor training adherence when voluntarily executed is recommended.
   
citation Schulz S V W, Schumann U, Otto S, Kirsten J, Treff G, Janni W, Huober J, Leinert E, Steinacker J M, Bizjak D A. Two-year follow-up after a six-week high-intensity training intervention study with breast cancer patients: physiological, psychological and immunological differences. Disabil Rehabil 2021;1-8.
   
type journal paper/review (English)
date of publishing 11-05-2021
journal title Disabil Rehabil
ISSN electronic 1464-5165
pages 1-8
PubMed 33974472
DOI 10.1080/09638288.2021.1921861