Reinnervation as measured by the motor unit size index is associated with preservation of muscle strength in amyotrophic lateral sclerosis, but not all muscles reinnervate
Young Chan, James J P Alix, Christoph Neuwirth, Paul E Barkhaus, José Castro, Thomas M Jenkins, Christopher J McDermott, Pamela J Shaw, Mamede De Carvalho, Sanjeev Nandedkar, Erik Stålberg & Markus Weber
MUSIX increases are associated with greater motor unit loss but relative preservation of muscle strength. Thus, MUSIX appears to be measuring a clinically relevant response that can provide a quantitative outcome measure of reinnervation in clinical trials. Furthermore, MUSIX suggests that reinnervation may play a major role in determining the progression of weakness.
|citation||Chan Y, Alix J J P, Neuwirth C, Barkhaus P E, Castro J, Jenkins T M, McDermott C J, Shaw P J, De Carvalho M, Nandedkar S, Stålberg E, Weber M. Reinnervation as measured by the motor unit size index is associated with preservation of muscle strength in amyotrophic lateral sclerosis, but not all muscles reinnervate. Muscle Nerve 2021; 65:203-210.|
|type||journal paper/review (English)|
|date of publishing||09-11-2021|
|journal title||Muscle Nerve (65/2)|