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Pattern of Care Study in Metastatic Renal-Cell Carcinoma in the Preimmunotherapy Era in Switzerland

Nadja Sandmeier, Sacha I Rothschild, Christian Rothermundt, Richard Cathomas, Julian Schardt, Dominik Berthold, Philippe Von Burg, Beat Müller, Jörg Beyer, Deborah R Vogt & Frank Stenner

abstract

INTRODUCTION
In metastatic renal-cell carcinoma (mRCC), physicians have a plethora of therapeutic choices, with the latest addition of checkpoint inhibitors. However, many questions regarding the best use of the respective drugs remain unanswered. Therefore, it is important to examine and summarize the outcome of real-world experiences to understand the practical value of the various drugs in daily use and foster optimal treatment algorithms for patients with renal-cell carcinoma. We sought to describe the pattern of care in mRCC under circumstances with access to all therapeutic options for patients.

PATIENTS AND METHODS
We examined the outcome of patients with mRCC who were treated at 8 major centers in Switzerland, mainly with vascular endothelial growth factor-targeted therapy and mammalian target of rapamycin inhibitors. Data from 110 patients with mRCC who had undergone more than one systemic therapy were collected and analyzed. We assessed the pattern of care for patients with mRCC in an unrestricted health care system and outcomes with regard to the respective treatment sequences. We also studied the compliance of individual therapies with published guidelines and correlated the adherence to outcome. Finally, immediate versus deferred treatment and the number of received therapeutic drug lines were analyzed.

RESULTS
Median survival of patients treated with targeted agents for mRCC was 2.0 years.

CONCLUSION
Exposure to more than 2 lines of systemic drugs did not improve outcome of patients with mRCC.
   
citation Sandmeier N, Rothschild S I, Rothermundt C, Cathomas R, Schardt J, Berthold D, von Burg P, Müller B, Beyer J, Vogt D R, Stenner F. Pattern of Care Study in Metastatic Renal-Cell Carcinoma in the Preimmunotherapy Era in Switzerland. Clin Genitourin Cancer 2018;.
   
type journal paper/review (English)
date of publishing 02-02-2018
journal title Clin Genitourin Cancer
ISSN electronic 1938-0682
PubMed 29503245
DOI 10.1016/j.clgc.2018.01.002