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Corona Immunitas: study protocol of a nationwide program of SARS-CoV-2 seroprevalence and seroepidemiologic studies in Switzerland

Erin A West, Daniela Anker, Rebecca Amati, Aude Richard, Ania Wisniak, Audrey Butty, Emiliano Albanese, Murielle Bochud, Arnaud Chiolero, Luca Crivelli, Stéphane Cullati, Valérie D'Acremont, Adina Mihaela Epure, Jan Fehr, Antoine Flahault, Luc Fornerod, Irène Frank, Anja Frei, Gisela Michel, Semira Gonseth, Idris Guessous, Medea Imboden, Christian R. Kahlert, Laurent Kaufmann, Philipp Kohler, Nicolai Mösli, Daniel Paris, Nicole Probst-Hensch, Nicolas Rodondi, Silvia Stringhini, Thomas Vermes, Fabian Vollrath, Milo A Puhan & Corona Immunitas Research Group

abstract

OBJECTIVES
Seroprevalence studies to assess the spread of SARS-CoV-2 infection in the general population and subgroups are key for evaluating mitigation and vaccination policies and for understanding the spread of the disease both on the national level and for comparison with the international community.

METHODS
Corona Immunitas is a research program of coordinated, population-based, seroprevalence studies implemented by Swiss School of Public Health (SSPH+). Over 28,340 participants, randomly selected and age-stratified, with some regional specificities will be included. Additional studies in vulnerable and highly exposed subpopulations are also planned. The studies will assess population immunological status during the pandemic.

RESULTS
Phase one (first wave of pandemic) estimates from Geneva showed a steady increase in seroprevalence up to 10.8% (95% CI 8.2-13.9, n = 775) by May 9, 2020. Since June, Zurich, Lausanne, Basel City/Land, Ticino, and Fribourg recruited a total of 5973 participants for phase two thus far.

CONCLUSIONS
Corona Immunitas will generate reliable, comparable, and high-quality serological and epidemiological data with extensive coverage of Switzerland and of several subpopulations, informing health policies and decision making in both economic and societal sectors. ISRCTN Registry: https://www.isrctn.com/ISRCTN18181860 .
   
citation West E A, Anker D, Amati R, Richard A, Wisniak A, Butty A, Albanese E, Bochud M, Chiolero A, Crivelli L, Cullati S, d'Acremont V, Epure A M, Fehr J, Flahault A, Fornerod L, Frank I, Frei A, Michel G, Gonseth S, Guessous I, Imboden M, Kahlert C R, Kaufmann L, Kohler P, Mösli N, Paris D, Probst-Hensch N, Rodondi N, Stringhini S, Vermes T, Vollrath F, Puhan M A, Corona Immunitas Research Group . Corona Immunitas: study protocol of a nationwide program of SARS-CoV-2 seroprevalence and seroepidemiologic studies in Switzerland. Int J Public Health 2020;.
   
type journal paper/review (English)
date of publishing 24-10-2020
journal title Int J Public Health
ISSN electronic 1661-8564
PubMed 33098441
DOI 10.1007/s00038-020-01494-0