Publication

Receptor-mediated targeting of cathepsins in professional antigen presenting cells

Journal Paper/Review - Jan 1, 2009

Units
PubMed
Doi

Citation
Hillaert U, Driessen C, van der Marel G, Ossendorp F, Van Calenbergh S, Kuiper J, Habets K, Saragliadis A, Saragliadis A, Florea B, Verdoes M, Overkleeft H. Receptor-mediated targeting of cathepsins in professional antigen presenting cells. Angewandte Chemie (International ed. in English) 2009; 48:1629-32.
Type
Journal Paper/Review (English)
Journal
Angewandte Chemie (International ed. in English) 2009; 48
Publication Date
Jan 1, 2009
Issn Electronic
1521-3773
Pages
1629-32
Brief description/objective

Tag for professionals: A fluorescently tagged clustered mannoside DCG-04 analogue (see structure) is designed and synthesized using a modular approach. Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose-receptor dependent manner.