Neural correlates of de novo depression following left temporal lobe epilepsy surgery: a voxel based morphometry study of pre-surgical structural MRI
Rebecca Anne Pope, Maria Centeno, Dominique Flügel, Mark Robert Symms, Matthias Koepp, Pamela Jane Thompson & Jacqueline Foong
Although the development of postoperative de novo depression following TLE surgery is likely to be multi-factorial, our results suggest that bilateral OFC and ipsilateral cingulate gyrus and thalamic atrophy in left-sided TLE patients may play a modulatory role. Abnormalities in these areas have also been implicated in primary mood disorders. Prospective neuroimaging studies with larger cohorts are warranted to replicate these results, and further elucidate the neural correlates of de novo depression.
|citation||Pope R A, Centeno M, Flügel D, Symms M R, Koepp M, Thompson P J, Foong J. Neural correlates of de novo depression following left temporal lobe epilepsy surgery: a voxel based morphometry study of pre-surgical structural MRI. Epilepsy Res 2013; 108:517-25.|
|type||journal paper/review (English)|
|date of publishing||27-12-2013|
|journal title||Epilepsy Res (108/3)|