Publication

Advances in Personalized Cancer Management

Book Chapter - Jan 1, 2011

Units
Doi
Link
Contact

Citation
Früh M, Baty F, Putora P, Brutsche M. Advances in Personalized Cancer Management. In: Advances in Personalized Cancer Management. NovemberLondon: Future Medicine Ltd, 2011. ISBN 978-1-78084-068-0. pp. 58-67.
Type
Book Chapter (English)
Book Title
Advances in Personalized Cancer Management
Publication Date
Jan 1, 2011
Volume
November
Isbn Number
978-1-78084-068-0
Pages
58-67
Publisher
Future Medicine Ltd (London)
Brief description/objective

The early identification of predictive molecular markers is crucial. Activating EGF receptor mutations and ALK gene rearrangements occur in a subset of patients with non-small-cell lung cancer and predict for benefit of the treatment with EGF receptor tyrosine kinase inhibitors and ALK inhibitors. The treatment of patients with resistance to these agents is currently a field of intensive research. Numerous other oncogenic driver mutations have been discovered and corresponding agents are currently being tested in preclinical and clinical studies. Genomics in lung cancer and the field of miRNA in particular hold great promise.