Kantonsspital St.Gallen

Beneficial Molecular Adaptations In -Mutation Carriers By Combined HIT/HIRT Intervention: Results From A Pilot Study

Daniel A Bizjak, Sebastian V W Schulz, Uwe Schumann, Stephanie Otto, Johannes Kirsten, Florian Ebner, Elena Leinert, Jens Huober, Wolfgang Janni & Jürgen Michael Steinacker

abstract Based on growing evidence that breast cancer (BRCA) also plays a pivotal role in the regulation of skeletal muscle metabolism and the response to anti-oxidative stress, we examined the influence of regular exercise in human mutation carriers on their BRCA1 gene/protein expression and inflammatory/oxidative response. Sixteen -mutation carriers were assigned to an intervention (IG) or control group (CG). IG received a combination of high-intensity interval endurance (HIT) and strength training (HIRT) for six weeks, whereas CG received a low-intensity activity program. Before (T0) and at the end of the intervention (T1), muscle biopsy, physiological performance, blood withdrawal and anthropometry were obtained. Parameters included: Muscle BRCA1 gene/protein expression, inflammatory/oxidative stress, anti-oxidative capacity, peak oxygen capacity (VOpeak) and 1-repetition maximum (1-RM) at six different training machines. VOpeak and 1-RM of IG were increased at T1 compared to T0, whereas CG performance, physiological and molecular parameters remained unchanged. IG showed increased BRCA1 protein concentration as well as anti-oxidative capacity, whereas gene expression was unaltered. IG inflammatory and oxidative damage did not differ between time points. Combined HIT/HIRT increases aerobic and strength performance of -mutation carriers with up regulated BRCA1 protein expression and improved anti-oxidative status without showing an increased inflammatory response.
citation Bizjak D A, Schulz S V W, Schumann U, Otto S, Kirsten J, Ebner F, Leinert E, Huober J, Janni W, Steinacker J M. Beneficial Molecular Adaptations In -Mutation Carriers By Combined HIT/HIRT Intervention: Results From A Pilot Study. Cancers (Basel) 2020; 12:.
type journal paper/review (English)
date of publishing 10-06-2020
journal title Cancers (Basel) (12/6)
ISSN print 2072-6694
PubMed 32532068
DOI 10.3390/cancers12061526