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Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) - Part 2 with Recommendations for the Therapy of Primary, Recurrent and Advanced Breast Cancer

Achim Wöckel, Jasmin Festl, Tanja Stüber, Katharina Brust, Mathias Krockenberger, Peter U Heuschmann, Steffi Jírů-Hillmann, Ute-Susann Albert, Wilfried Budach, Markus Follmann, Wolfgang Janni, Ina Kopp, Rolf Kreienberg, Thorsten Kühn, Thomas Langer, Monika Nothacker, Anton Scharl, Ingrid Schreer, Hartmut Link, Jutta Engel, Tanja Fehm, Joachim Weis, Anja Welt, Anke Steckelberg, Petra Feyer, Klaus König, Andrea Hahne, Traudl Baumgartner, Hans H Kreipe, Wolfram Trudo Knoefel, Michael Denkinger, Sara Brucker, Diana Lüftner, Christian Kubisch, Christina Gerlach, Annette Lebeau, Friederike Siedentopf, Cordula Petersen, Hans Helge Bartsch, Rüdiger Schulz-Wendtland, Markus Hahn, Volker Hanf, Markus Müller-Schimpfle, Ulla Henscher, Renza Roncarati, Alexander Katalinic, Christoph Heitmann, Christoph Honegger, Kerstin Paradies, Vesna Bjelic-Radisic, Friedrich Degenhardt, Frederik Wenz, Oliver Rick, Dieter Hölzel, Matthias Zaiss, Gudrun Kemper, Volker Budach, Carsten Denkert, Bernd Gerber, Hans Tesch, Susanne Hirsmüller, Hans-Peter Sinn, Jürgen Dunst, Karsten Münstedt, Ulrich Bick, Eva Fallenberg, Reina Tholen, Roswita Hung, Freerk Baumann, Matthias W Beckmann, Jens Blohmer, Peter Fasching, Michael P Lux, Nadia Harbeck, Peyman Hadji, Hans Hauner, Sylvia Heywang-Köbrunner, Jens Huober, Jutta Hübner, Christian Jackisch, Sibylle Loibl, Hans-Jürgen Lück, Gunter Von Minckwitz, Volker Möbus, Volkmar Müller, Ute Nöthlings, Marcus Schmidt, Rita Schmutzler, Andreas Schneeweiss, Florian Schütz, Elmar Stickeler, Christoph Thomssen, Michael Untch, Simone Wesselmann, Arno Bücker, Andreas Buck & Stephanie Stangl

abstract The aim of this official guideline coordinated and published by the German Society for Gynecology and Obstetrics (DGGG) and the German Cancer Society (DKG) was to optimize the screening, diagnosis, therapy and follow-up care of breast cancer. The process of updating the S3 guideline published in 2012 was based on the adaptation of identified source guidelines. They were combined with reviews of evidence compiled using PICO (Patients/Interventions/Control/Outcome) questions and with the results of a systematic search of literature databases followed by the selection and evaluation of the identified literature. The interdisciplinary working groups took the identified materials as their starting point and used them to develop suggestions for recommendations and statements, which were then modified and graded in a structured consensus process procedure. Part 2 of this short version of the guideline presents recommendations for the therapy of primary, recurrent and metastatic breast cancer. Loco-regional therapies are de-escalated in the current guideline. In addition to reducing the safety margins for surgical procedures, the guideline also recommends reducing the radicality of axillary surgery. The choice and extent of systemic therapy depends on the respective tumor biology. New substances are becoming available, particularly to treat metastatic breast cancer.
   
citation Wöckel A, Festl J, Stüber T, Brust K, Krockenberger M, Heuschmann P U, Jírů-Hillmann S, Albert U S, Budach W, Follmann M, Janni W, Kopp I, Kreienberg R, Kühn T, Langer T, Nothacker M, Scharl A, Schreer I, Link H, Engel J, Fehm T, Weis J, Welt A, Steckelberg A, Feyer P, König K, Hahne A, Baumgartner T, Kreipe H H, Knoefel W T, Denkinger M, Brucker S, Lüftner D, Kubisch C, Gerlach C, Lebeau A, Siedentopf F, Petersen C, Bartsch H H, Schulz-Wendtland R, Hahn M, Hanf V, Müller-Schimpfle M, Henscher U, Roncarati R, Katalinic A, Heitmann C, Honegger C, Paradies K, Bjelic-Radisic V, Degenhardt F, Wenz F, Rick O, Hölzel D, Zaiss M, Kemper G, Budach V, Denkert C, Gerber B, Tesch H, Hirsmüller S, Sinn H P, Dunst J, Münstedt K, Bick U, Fallenberg E, Tholen R, Hung R, Baumann F, Beckmann M W, Blohmer J, Fasching P, Lux M P, Harbeck N, Hadji P, Hauner H, Heywang-Köbrunner S, Huober J, Hübner J, Jackisch C, Loibl S, Lück H J, von Minckwitz G, Möbus V, Müller V, Nöthlings U, Schmidt M, Schmutzler R, Schneeweiss A, Schütz F, Stickeler E, Thomssen C, Untch M, Wesselmann S, Bücker A, Buck A, Stangl S. Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) - Part 2 with Recommendations for the Therapy of Primary, Recurrent and Advanced Breast Cancer. Geburtshilfe Frauenheilkd 2018; 78:1056-1088.
   
type journal paper/review (English)
date of publishing 26-11-2018
journal title Geburtshilfe Frauenheilkd (78/11)
ISSN print 0016-5751
pages 1056-1088
PubMed 30581198
DOI 10.1055/a-0646-4630