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Circulating Tumour Cells, Circulating Tumour DNA and Circulating MicroRNA in Metastatic Breast Carcinoma - What is the Role of Liquid Biopsy in Breast Cancer?

Arkadius Polasik, Marie Tzschaschel, Fabienne Schochter, Amelie De Gregorio, Thomas W P Friedl, Brigitte Rack, Andreas Hartkopf, Peter A Fasching, Andreas Schneeweiss, Volkmar Müller, Jens Huober, Wolfgang Janni & Tanja Fehm

abstract Dissemination of tumour cells and the development of solid metastases occurs via blood vessels and lymphatics. Circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA) can be detected in venous blood in patients with early and metastatic breast cancer, and their prognostic relevance has been demonstrated on numerous occasions. Repeated testing for CTCs and ctDNA, or regular so-called "liquid biopsy", can be performed easily at any stage during the course of disease. Additional molecular analysis allows definition of tumour characteristics and heterogeneity that may be associated with treatment resistance. This in turn makes personalised, targeted treatments possible that may achieve both improved overall survival and quality of life.
   
citation Polasik A, Tzschaschel M, Schochter F, De Gregorio A, Friedl T W P, Rack B, Hartkopf A, Fasching P A, Schneeweiss A, Müller V, Huober J, Janni W, Fehm T. Circulating Tumour Cells, Circulating Tumour DNA and Circulating MicroRNA in Metastatic Breast Carcinoma - What is the Role of Liquid Biopsy in Breast Cancer?. Geburtshilfe Frauenheilkd 2017; 77:1291-1298.
   
type journal paper/review (English)
date of publishing 18-12-2017
journal title Geburtshilfe Frauenheilkd (77/12)
ISSN print 0016-5751
pages 1291-1298
PubMed 29269956
DOI 10.1055/s-0043-122884