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Prospective real-world study on the pharmacokinetics of pembrolizumab in patients with solid tumors

Daan P Hurkmans, Sebastiaan D T Sassen, Karlijn De Joode, Lisanne Putter, Edwin A Basak, Annemarie J M Wijkhuijs, Markus Joerger, Reno Debets, Birgit C P Koch, Cor H Van Der Leest, Marco W J Schreurs, Astrid A M Van Der Veldt, Joachim G J V Aerts, Ron H J Mathijssen & Stijn L W Koolen

abstract

BACKGROUND
Dosing schemes of pembrolizumab (anti-programmed cell death protein 1 monoclonal antibody) are solely based on pharmacokinetic (PK) modelling derived from phase I-III trials. The current study aimed to determine factors affecting PK and its relationship with clinical outcome in the real-world setting.

METHODS
Advanced-stage cancer patients, who were treated with pembrolizumab monotherapy (2 mg/kg Q3W or 200 mg flat Q3W), were prospectively included for serial sampling to obtain trough concentrations. A PK model was generated, covariate effects assessed and internally validated by a bootstrap procedure. PK parameters were related to overall survival (OS) and the occurrence of immune-related adverse events (irAEs).

RESULTS
588 serum samples derived from 122 patients with (non-)small-cell lung cancer ([N]SCLC), malignant pleural mesothelioma (MPM), melanoma and urothelial cell cancer (UCC) were analyzed. Median follow-up was 2.2 years. A one-compartment PK model was generated: body surface area (BSA) and serum albumin had a significant effect on drug clearance (CL; covariate estimate 1.46 and -1.43, respectively), and serum lactate dehydrogenase (LDH) on the distribution volume(V; 0.34). A significant inverse CL-OS relationship was determined for NSCLC (HR:1.69; 95%CI1.07-2.68; p=0.024) and MPM (HR: 3.29; 95% CI 1.08 to 10.09; p=0.037), after correction for prognostic factors, which could not confirmed for melanoma (p=0.22) or UCC (p=0.34). No relationship could be determined between CL and grade 3 irAEs (p=0.70).

CONCLUSIONS
High interpatient variability of pembrolizumab PK is determined by BSA and serum albumin (on CL) and LDH (on V). A strong inverse CL-OS relationship was demonstrated for NSCLC and MPM, which could not be observed for melanoma and UCC. The findings suggest that personalized dosing should be prospectively explored.
   
citation Hurkmans D P, Sassen S D T, De Joode K, Putter L, Basak E A, Wijkhuijs A J M, Joerger M, Debets R, Koch B C P, Van Der Leest C H, Schreurs M W J, Van Der Veldt A A M, Aerts J G J V, Mathijssen R H J, Koolen S L W. Prospective real-world study on the pharmacokinetics of pembrolizumab in patients with solid tumors. J Immunother Cancer 2021; 9:.
   
type journal paper/review (English)
date of publishing 2021
journal title J Immunother Cancer (9/6)
ISSN electronic 2051-1426
PubMed 34088739
DOI 10.1136/jitc-2021-002344