Dosing algorithm to target a predefined AUC in patients with primary central nervous system lymphoma receiving high dose methotrexate
Markus Joerger, Andrés J M Ferreri, Stephan Krähenbühl, Jan H M Schellens, Thomas Cerny, Emanuele Zucca & Alwin D R Huitema
A simple and practical dosing algorithm for HDMTX has been developed based on MTX 24 h plasma concentrations, and its potential efficacy in improving the proportion of patients within a prespecified target AUC(MTX) and reducing the interindividual variability of MTX exposure has been shown by data simulations. The clinical benefit of this dosing algorithm should be assessed in patients with primary central nervous system lymphoma (PCNSL).
|citation||Joerger M, Ferreri A J M, Krähenbühl S, Schellens J H M, Cerny T, Zucca E, Huitema A D R. Dosing algorithm to target a predefined AUC in patients with primary central nervous system lymphoma receiving high dose methotrexate. Br J Clin Pharmacol 2012; 73:240-7.|
|type||journal paper/review (English)|
|date of publishing||2-2012|
|journal title||Br J Clin Pharmacol (73/2)|