Pharmacokinetics of Selected Anticancer Drugs in Elderly Cancer Patients: Focus on Breast Cancer
Marie-Rose B S Crombag, Markus Joerger, Beat Thuerlimann, Jan H M Schellens, Jos H Beijnen & Alwin D R Huitema
Selected published data revealed differences in the effect and magnitude of increasing age on the PK of several anticancer drugs. There may be clinically-relevant, age-related PK differences for anthracyclines and platina agents. In the majority of cases, age is not a good surrogate marker for anticancer drug PK, and the physiological state of the individual patient may better be approached by looking at organ function, Charlson Comorbidity Score or geriatric functional assessment.
|citation||Crombag M R B S, Joerger M, Thuerlimann B, Schellens J H M, Beijnen J H, Huitema A D R. Pharmacokinetics of Selected Anticancer Drugs in Elderly Cancer Patients: Focus on Breast Cancer. Cancers (Basel) 2016; 8:.|
|type||journal paper/review (English)|
|date of publishing||02-01-2016|
|journal title||Cancers (Basel) (8/1)|