Kantonsspital St.Gallen
login

Time to systemic treatment and prognosis in patients with recurrent and metastatic head and neck squamous cell cancer

Marco Siano, Vittoria Espeli & Markus Joerger

abstract

BACKGROUND:
Delay of systemic treatment in recurrent/metastatic head and neck squamous cell cancer (r/mHNSCC) has never been assessed. Whether time span to start systemic treatment affects survival and whether referral to a medical oncologist is important has not been explored.

METHODS:
We analyzed our head and neck database to assess the prognostic impact of time between diagnosis of r/mHNSCC and start of systemic treatment (time to treatment [TTT]). Secondarily, we assessed the prognostic impact of time to referral to a medical oncologist (referral time). For this purpose, we used pairwise correlation analysis and multivariate Cox regression analysis as statistical tests.

RESULTS:
A total of 110 patients with r/mHNSCC were evaluable for analysis. TTT correlated significantly with OS from r/mHNSCC diagnosis ( R = .43, p < .0001). A nonsignificant, positive correlation was found between referral time and OS ( R = .17, p = .10).

CONCLUSIONS:
Results of this retrospective analysis suggest that longer TTT is not associated with worse prognosis. Referral time seems not to have an impact on prognosis.
   
citation Siano M, Espeli V, Joerger M. Time to systemic treatment and prognosis in patients with recurrent and metastatic head and neck squamous cell cancer. Tumori 2018;300891618811276.
   
type journal paper/review (English)
date of publishing 26-11-2018
journal title Tumori
ISSN electronic 2038-2529
pages 300891618811276
PubMed 30474503
DOI 10.1177/0300891618811276