Role of family planning in women of child-bearing age with multiple sclerosis (MS) in Switzerland: Results of the Women
Sarah Muehl, Adam Czaplinski, Petra Stelmess, Christian P. Kamm, Stefanie Müller & Sarah Muehl
OBJECTIVE: The WWMS patient survey aimed to improve understanding of
factors which affect family planning in women of child-bearing age
BACKGROUND: Many women with MS are of child-bearing age and may desire to conceive.
METHODS: Women with MS, aged 18-50 years, at 15 centres in Switzerland were surveyed.
RESULTS: Between September 2014 and August 2015, 271 females (79.3% [n=215] of child-bearing age [18–45 years]), who had CIS (n=7), RRMS (n=249), SPMS (n=6) or not known (n=9), regardless of MS treatment, completed the WWMS survey. Overall, a total of 39.1% (n=106) women were pregnant or wanted children (1.5% [n=4] pregnant, 21.4% [n=58] short-term desire [std], 16.2% [n=44] medium-term desire [mtd]), 43.2% (n=117) had no desire (nd) for children and 17.7% (n=48) did not know (nk). Between age 18–45 years, 48.4% (n=104) wanted children or were pregnant. 92.3% (n=250) were treated with disease modifying therapy (DMT), and 7.7% (n=21) not treated with DMT (including the 4 women who were pregnant). Treatment included injectables (intramuscular IFN β-1a, subcutaneous IFN β-1b, subcutaneous IFN β-1a, glatiramer acetate) (nd n=19; std n=19; mtd n=9; nk n=7), orals (teriflunomide, fingolimod, dimethyl fumarate) (nd n=34; std n=13; mtd n=15; nk n=14), infusions (natalizumab) (nd n=41; std n=16; mtd n=14; nk n=17) and other (nd n=14; std n=6; mtd n=6; nk n=6). Oral treatment was significantly more common in women with no desire for children versus short- and medium-term desire (p<0.01 for both). In 15.3% (n=9) of women a previous pregnancy had been unplanned/unintended.
CONCLUSIONS: Over one-third of women with MS were pregnant or desired children, and nearly all received DMT independent of desire for children. The intention to have children within 2 years influenced treatment choice towards injectables over orals. Issues surrounding pregnancy influences therapy choice in women of child-bearing age with MS.
|citation||Muehl S, Czaplinski A, Stelmess P, Kamm C P , Müller S, & Muehl S (2016). Role of family planning in women of child-bearing age with multiple sclerosis (MS) in Switzerland: Results of the Women. In (pp. 1): keiner.|
|type||conference paper/poster (English)|
|name of conference||American Academy of Neurology AAN (Vancouver, B.C: Canada, AAN, 15–21 April 2016, Abstract No. 1735)|
|date of conference||17-4-2016|