Publication

[Severe SGLT-2 inhibitor-induced euglycemic ketoacidosis-a rare but serious complication]

Journal Paper/Review - Dec 5, 2019

Units
PubMed
Doi

Citation
Rotsel E, Pietsch U. [Severe SGLT-2 inhibitor-induced euglycemic ketoacidosis-a rare but serious complication]. Anaesthesist 2019
Type
Journal Paper/Review (Deutsch)
Journal
Anaesthesist 2019
Publication Date
Dec 5, 2019
Issn Electronic
1432-055X
Brief description/objective

Ketoacidosis induced by sodium-glucose cotransporter‑2 inhibitors (SGLT-2i) is rare. If it occurs, it is a serious clinical condition which requires immediate and correct treatment. At the moment, the occurrence of a ketoacidotic crisis necessitates permanent removal of the SGLT-2i from the patient's medication. Clear recommendations concerning the timing of discontinuation of SGLT-2i prior to planned surgical interventions are lacking. The tendency towards the undesirable effects of the medication in stressful situations is impressive. Currently, SGLT-2i are recognized as established oral antidiabetics and are becoming more popular. Clinicians should be aware of and alert to the diagnosis of ketoacidosis with normal blood glucose measurements in diabetic patients showing unspecific symptoms under administration of SGLT-2i.