The History of Target-Controlled Infusion

Publication

The History of Target-Controlled Infusion

Journal Paper/Review - Jan 1, 2016

Struys Michel M R F, De Smet Tom, Glen John Iain B, Vereecke Hugo E M, Absalom Anthony R, Schnider Thomas

Citation

Struys M, De Smet T, Glen J, Vereecke H, Absalom A, Schnider T. The History of Target-Controlled Infusion. Anesth Analg 2016; 122:56-69.

Type

Journal Paper/Review (English)

Journal

Anesth Analg 2016; 122

Publication Date

Jan 1, 2016

Issn Electronic

1526-7598

Pages

56-69

Brief description/objective

Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted ("target") drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical and regulatory issues addressed in prototype development. We also describe the launch of the current clinically available systems.