Three-dimensional contrast-enhanced MRI using an intravascular contrast agent for detection of traumatic intra-abdominal hemorrhage and abdominal parenchymal injuries: an experimental study

Publication

Three-dimensional contrast-enhanced MRI using an intravascular contrast agent for detection of traumatic intra-abdominal hemorrhage and abdominal parenchymal injuries: an experimental study

Journal Paper/Review - Jan 1, 2000

Weishaupt D, Hetzer Franc, Ruehm S G, Patak M A, Schmidt M, Debatin J F

Units

Clinic for General, Visceral, Endocrine and Transplant Surgery

PubMed

11305579

Citation

Weishaupt D, Hetzer F, Ruehm S, Patak M, Schmidt M, Debatin J. Three-dimensional contrast-enhanced MRI using an intravascular contrast agent for detection of traumatic intra-abdominal hemorrhage and abdominal parenchymal injuries: an experimental study. European radiology 2000; 10:1958-64.

Type

Journal Paper/Review (English)

Journal

European radiology 2000; 10

Publication Date

Jan 1, 2000

Issn Print

0938-7994

Pages

1958-64

Brief description/objective

The aim of this study was to compare the performance of 3D MRI in conjunction with an intravascular contrast agent to spiral contrast-enhanced CT, regarding the detection of abdominal parenchymal injuries as well as peritoneal hemorrhage in an animal model. Liver and kidney injuries were created surgically in six female pigs under general anesthesia. All pigs underwent contrast-enhanced spiral CT and 3D MR imaging following administration of an intravascular contrast agent (NC100150 Injection). Two readers rated their confidence independently on MR and CT data sets using a five-point scale for the presence of organ injury and hemoperitoneum. Autopsy findings served as standard of reference. Sensitivity and specificity for MR in detecting hepatic and renal injuries as well as hemoperitoneum was 100%. Computed tomography was less accurate with sensitivity and specificity values of 90 and 94%, respectively. Receiver operating characteristics (ROC) analysis revealed a higher confidence when interpretation was based on MR images. In an animal model 3D MR imaging in conjunction with an intravascular contrast agent proved highly accurate in detecting and localizing parenchymal injuries to the upper abdomen as well as in detecting intraperitoneal blood collections.