Publication

Increase in bone mineral density after successful parathyroidectomy for tertiary hyperparathyroidism after renal transplantation

Journal Paper/Review - Aug 1, 2008

Units
PubMed
Doi

Citation
Collaud S, Robert J, Martin P, Rizzoli R, Myers P, Binet F, Marangon N, Clerici T, Trombetti A, Staub-Zähner T, Triponez F. Increase in bone mineral density after successful parathyroidectomy for tertiary hyperparathyroidism after renal transplantation. World journal of surgery 2008; 32:1795-801.
Type
Journal Paper/Review (English)
Journal
World journal of surgery 2008; 32
Publication Date
Aug 1, 2008
Issn Print
0364-2313
Pages
1795-801
Brief description/objective

BACKGROUND: Few studies have reported changes of bone mineral density (BMD) after parathyroidectomy in patients with persistent hyperparathyroidism after renal transplantation (3 HPT). PATIENTS AND METHODS: We retrospectively analyzed 14 patients who underwent successful parathyroidectomy for 3 HPT and who had available BMD data before and after parathyroidectomy. RESULTS: Median follow-up time was 26 months (IQR: 16.8-40.2). Serum calcium levels decreased significantly after parathyroidectomy (2.32 +/- 0.09 versus 2.66 +/- 0.16 mmol/l; p < 0.01), as did PTH levels (5.1 +/- 3.0 versus 27.8 +/- 23.7 pmol/l; p < 0.01). Nine patients (64%) had a steroid-free immunosuppression at follow-up. Mean increase in BMD was 9.5 +/- 8.0% for the spine and 9.5 +/- 7.9% for the hip (p < 0.01 for both sites). Patients with osteoporosis (T-score