Endolumenal colon occlusion device for transanal and transrectal surgery--a porcine feasibility study

Publication

Endolumenal colon occlusion device for transanal and transrectal surgery--a porcine feasibility study

Journal Paper/Review - Mar 13, 2013

Linke Georg R, Senft Jonas, Kenngott Hannes G, Lasitschka Felix, Warschkow Rene, Shevchenko Maxym, Zerz Andreas, Kähler Georg, Carstensen Benedict, Müller-Stich Beat P

Citation

Linke G, Senft J, Kenngott H, Lasitschka F, Warschkow R, Shevchenko M, Zerz A, Kähler G, Carstensen B, Müller-Stich B. Endolumenal colon occlusion device for transanal and transrectal surgery--a porcine feasibility study. Langenbecks Arch Surg 2013; 398:595-601.

Type

Journal Paper/Review (English)

Journal

Langenbecks Arch Surg 2013; 398

Publication Date

Mar 13, 2013

Issn Electronic

1435-2451

Pages

595-601

Brief description/objective

PURPOSE
Although several studies have demonstrated the feasibility of transrectal natural orifice translumenal endoscopic surgery (NOTES), its clinical application has been hindered by concerns regarding potential infectious complications. The aim of this study was to evaluate the feasibility of a newly developed device for endolumenal colon occlusion (ColoShield) in an acute porcine model.

METHODS
The principle of the ColoShield device is based on two balloons, with negative pressure in between. The ColoShield device and a gauze tamponade as a control group were evaluated in a non-survival study on 16 pigs. The efficacy of the occlusion system in establishing a leak-proof pneumorectum and in sealing the colon from proximal (watertight sealing) was tested by a standardized study course. Finally, the colon/rectum was explanted for macroscopic and microscopic examination.

RESULTS
A 20-mmHg leak-proof pneumorectum over a period of 10 min could be achieved in seven of eight (87 %) animals with the ColoShield device and in none of eight (0 %) animals with gauze tamponade (p < 0.001). In the watertight sealing test, mean intracolonic pressures of 23.5 ± 18.1 (0-53) mmHg using the ColoShield device and 0 ± 1.1 (0-3) mmHg using gauze tamponade (p = 0.003) were documented proximal to the occlusion system before a leakage occurred. Macroscopic and histopathological examinations revealed no significant impairment of the colon specimen in either group.

CONCLUSIONS
ColoShield proved to be a safe and effective device for a reversible endolumenal colon occlusion. Further studies should evaluate its impact on procedural sterility during transrectal NOTES.