Publication

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

Journal Paper/Review - Apr 27, 2017

Units
PubMed
Doi

Citation
Uitterlinden A, Thuillier D, Thorand B, Tan S, Tammelin T, Swift A, Sternfeld B, Stančáková A, Snieder H, Smith J, Smith B, Silbernagel G, Sidney S, Shuldiner A, Sanna S, Scott W, Vandenput L, Vestergaard H, van Vliet-Ostaptchouk J, Rivadeneira F, Hofman A, Ohlsson C, Gyllensten U, Lemarchand L, Haiman C, Zubair N, Zillikens M, Wright A, Wong A, Wild S, Walker M, Waeber G, Völker U, Vohl M, Savonen K, Sarzynski M, Olden M, Oldehinkel A, Nolte I, Nettleton J, Nauck M, Narisu N, Männistö S, Männikkö R, Musk A, Müller-Nurasyid M, Mulas A, De Moor M, Montgomery G, Monda K, Milaneschi Y, Ong K, Padmanabhan S, Paternoster L, Sarti C, Rudan I, Rose L, Ridker P, Rawal R, Rasmussen-Torvik L, Rankinen T, Raitakari O, Puolijoki H, Prokopenko I, Peyser P, Peters U, Peters A, Perola M, Perez J, Marre M, Pérusse L, Kilpeläinen T, Barroso I, Abecasis G, Chasman D, Boerwinkle E, Porteous D, Weir D, Langenberg C, Wareham N, Metspalu A, Pedersen O, Hansen T, Hallmans G, Vollenweider P, Kooperberg C, McCarthy M, Frayling T, O'Connell J, Loos R, Cupples L, North K, Franks P, Borecki I, Johnson A, Klein R, Hirschhorn J, Liu C, Fox C, Strachan D, Mohlke K, Heid I, Boehnke M, van Duijn C, Froguel P, Kooner J, de Geus E, Penninx B, Salomaa V, Tuomilehto J, Sørensen T, Rauramaa R, Kardia S, Palmer L, Bandinelli S, Tönjes A, Hartman C, Hveem K, Cucca F, Polasek O, Hayward C, Boomsma D, Lehtimäki T, Mangino M, Chambers J, Jarvelin M, Qi L, Völzke H, Gudnason V, Harris T, Kivimäki M, Strauch K, März W, Linneberg A, Liu Y, Kuh D, Martin N, Bouchard C, Laakso M, Wilson J, Cheng Y, Wu Y, Peyrot W, Willemsen G, Huppertz C, Lyytikäinen L, Stringham H, Zhao J, Whitfield J, Rivera N, Lohman K, Hollensted M, Kleber M, Justesen J, Harder M, Kumari M, Kristiansson K, Demirkan A, Fornage M, Snitker S, Johansson Å, Pasko D, Bellis C, Navarro P, Marten J, Vitart V, Bragg-Gresham J, Jackson A, van der Most P, Mägi R, Tanaka T, Cadby G, Bielak L, Hassinen M, Smith A, Teumer A, Qi Q, Ahluwalia T, den Hoed M, Heard-Costa N, Workalemahu T, Xue L, Hadley D, Mahajan A, Chu A, Winkler T, Barata L, Feitosa M, Young K, Justice A, Scott R, Ngwa J, Renström F, Quaye L, Yengo L, Bien S, Marques-Vidal P, Ahmad S, Haller T, Griffin P, Zhao W, Zhang W, Huffman J, Luan J, Lim E, Kutalik Z, Cornelis M, Hayes J, Eicher J, Graff M, Eriksson J, Luben R, Hui J, Huang T, Huang J, Hottenga J, Holzapfel C, Holmens O, Hocking L, Hindorff L, Hernandez D, Havulinna A, Hastie N, Harald K, van Grootheest G, Grarup N, Grammer T, Huth C, Hutri-Kähönen N, James A, Lorentzon M, Lindgren C, Lehne B, Launer L, Lakka T, Kähönen M, Kvaløy K, Kuusisto J, Komulainen P, Kolcic I, Koistinen H, Kinnunen L, Juonala M, Jhun M, Jansson J, Grallert H, Gordon-Larsen P, Busonero F, Brage S, Borja J, Bonnycastle L, Bonnefond A, Blangero J, Bertoni A, Bergmann S, Bergman R, Beilby J, Auvinen J, Balkau B, Amin N, Adair L, Aadahl M, Buyske S, Campbell H, Chines P, Gong J, Gläser S, Gieger C, Færch K, Fu M, Faul J, Esko T, Eiriksdottir G, Ebeling T, Dörr M, Dueker N, Delgado G, Smith G, Corre T, Collins F, Lim U. Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet 2017; 13:e1006528.
Type
Journal Paper/Review (English)
Journal
PLoS Genet 2017; 13
Publication Date
Apr 27, 2017
Issn Electronic
1553-7404
Pages
e1006528
Brief description/objective

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.